Pharmacokinetics of 3′-azido-2′,3′-dideoxy-5-methylcytidine in Rats
نویسندگان
چکیده
منابع مشابه
Pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys.
2',3'-Dideoxy-5-fluoro-3'-thiacytidine (FTC) is a nucleoside analog that selectively inhibits human immunodeficiency and hepatitis B viruses in vitro. In this study, the preclinical pharmacokinetics of racemic FTC in rhesus monkeys following intravenous and oral administration were characterized. The terminal half-life of FTC was independent of the route of administration and averaged 1.34 +/- ...
متن کاملPharmacology and Pharmacokinetics of the Antiviral Agent -D-2 ,3 -Dideoxy-3 -Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys†
10.1128/AAC.49.7.2589-2597.2005. 2005, 49(7):2589. DOI: Antimicrob. Agents Chemother. Raymond F. Schinazi Harold M. McClure, Chung K. Chu, Dennis C. Liotta and Thierry Beltran, Shuli Mao, Selwyn J. Hurwitz, Jason Grier, Brenda I. Hernandez-Santiago, Huachun Chen, Ghazia Asif, Monkeys -Oxa-5-Fluorocytidine in Cells and Rhesus ′ -Dideoxy-3 ′ ,3 ′ -d-2 β Antiviral Agent Pharmacology and Pharmacoki...
متن کامل5-Azido-4-benzyloxy-2-methoxy-6-methylperhydropyran-3-ol
In the title compound, C(14)H(19)N(3)O(4), the perhydro-pyran ring adopts a chair conformation. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring motif. In the crystal packing, mol-ecules are linked by O-H⋯O hydrogen bonds, forming infinite chains along [100].
متن کامل5'-Nor carbocyclic 5'-deoxy-5'-(isobutylthio)adenosine and a 2',3'-dideoxy-2',3'-didehydro derivative.
The inhibition of biochemical processes requiring S-adenosylmethionine as a co-factor have led to many nucleoside-based medicinal agents. Included in this group are 5'-deoxy-5'-(isobutylthio)adenosine (SIBA), a nucleoside with antiparasitic, antiviral and antiproliferative effects, and 5'-noraristeromycin, a carbocyclic-derived nucleoside with potent antiviral properties. This report brings tog...
متن کاملPharmacology and pharmacokinetics of the antiviral agent beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine in cells and rhesus monkeys.
Beta-D-2',3'-dideoxy-3'-oxa-5-fluorocytidine (D-FDOC) is an effective inhibitor of human immunodeficiency virus 1 (HIV-1) and HIV-2, simian immunodeficiency virus, and hepatitis B virus (HBV) in vitro. The purpose of this study was to evaluate the intracellular metabolism of d-FDOC in human hepatoma (HepG2), human T-cell lymphoma (CEM), and primary human peripheral blood mononuclear (PBM) cells...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antiviral Chemistry and Chemotherapy
سال: 1990
ISSN: 2040-2066,2040-2066
DOI: 10.1177/095632029000100605